Aspirin resistance may be associated with:

Aspirin is commonly used as an antiplatelet medication to prevent clots from forming, especially in patients at risk for cardiovascular events. Aspirin works primarily by inhibiting cyclooxygenase-1 (COX-1), which decreases the production of thromboxane A2, a potent platelet aggregator. When a patient exhibits aspirin resistance, it means that aspirin is less effective in inhibiting platelet function, leading to an increased risk of thrombus formation.

The association between aspirin resistance and thrombosis arises from the fact that when aspirin fails to adequately inhibit platelet activation and aggregation, the likelihood of blood clots forming rises significantly. This can lead to serious cardiovascular events, including heart attacks and strokes, particularly in individuals with underlying cardiovascular disease.

In contrast, the other options do not have a direct relationship with the concept of aspirin resistance. Bleeding generally results from excessive inhibition of platelet function rather than resistance. Factor VIII deficiency relates to a bleeding disorder associated with hemophilia and does not connect with the efficacy of aspirin. Thrombocytosis, which involves an increased platelet count, may predispose a patient to clotting but is not a direct consequence of aspirin not working. Therefore, the clear link between aspirin resistance and increased risk of thromb