Diagnosis of lupus anticoagulant is confirmed by which of the following criteria?

The confirmation of lupus anticoagulant (LA) diagnosis primarily hinges on the demonstration that the anticoagulant activity can be neutralized by the presence of high concentrations of phospholipids. This is integral to understanding that LA functions through an interference mechanism where the antibody reacts with phospholipid components of the coagulation cascade.

Higher concentrations of platelets provide extra phospholipids that can effectively neutralize the lupus anticoagulant, thereby enabling a more accurate assessment of the underlying coagulation issue. Consequently, if the abnormal clotting test results normalize in such conditions, it supports the presence of a lupus anticoagulant. This diagnostic criterion is key as it differentiates LA from other causes of anticoagulant effects observed in the laboratory tests.