Fletcher factor (prekallikrein) deficiency may be associated with:

Fletcher factor, also known as prekallikrein, is involved in the intrinsic pathway of the coagulation cascade and plays a crucial role in the activation of clotting factors. A deficiency in prekallikrein can lead to a prothrombic state, meaning it may increase the risk of thrombosis rather than bleeding. This is due to its role in regulating coagulation; a deficiency can disrupt the balance of clot formation and resolution.

Individuals with Fletcher factor deficiency might experience an increased tendency to form clots, leading to conditions such as deep vein thrombosis or pulmonary embolism. Therefore, the association of Fletcher factor deficiency with thrombosis is understandable, as the overall coagulation process is disrupted, enhancing clotting risks.

In contrast, conditions like bleeding, thrombocytopenia (low platelet count), or thrombocytosis (high platelet count) are less directly associated with this coagulation factor deficiency and do not reflect its primary impact on the hemostatic process. This highlights the specific nature of prekallikrein's function and its consequences on thrombotic risk when deficient.