In von Willebrand's disease, which factor also becomes decreased?

Von Willebrand's disease is a genetic disorder that affects the blood's ability to clot effectively due to a deficiency or dysfunction of von Willebrand factor (vWF). This factor plays a crucial role in platelet adhesion—the initial step in the clotting process. It also serves as a carrier for Factor VIII, which is essential for the normal coagulation cascade.

In von Willebrand's disease, the deficiency or abnormal function of vWF leads to a decrease in Factor VIII levels. Since vWF stabilizes Factor VIII in circulation, a lack of adequate vWF results in reduced levels of Factor VIII, leading to an increased risk of bleeding. This relationship is critical to understanding the pathology of von Willebrand's disease, as it highlights the connection between vWF and Factor VIII, marking the decreased level of Factor VIII as a key feature of the disorder. Therefore, it is this connection that answers the question correctly.