In which of the following conditions is factor V deficiency primarily suspected?

Factor V deficiency is primarily suspected in conditions where there is prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). This deficiency is a rare inherited bleeding disorder that affects the body’s ability to form blood clots effectively. When the PT and APTT are prolonged, it indicates a defect in the intrinsic and/or extrinsic pathways of coagulation, which may be due to the lack of factor V.

In the case of factor V deficiency, both PT and APTT can be affected because factor V plays a vital role in both pathways of the coagulation cascade. The prolongation of these tests raises suspicion of a coagulopathy, leading to further testing for specific factors, including factor V.

Other conditions mentioned may also involve coagulopathy, but they do not specifically lead to the suspicion of factor V deficiency as definitively as the presence of prolonged PT and APTT. Therefore, this understanding is critical for the diagnosis and management of bleeding disorders in hematology.