Lupus anticoagulant is most commonly associated with which condition?

Lupus anticoagulant is an antibody that increases the risk of thrombosis rather than bleeding. It is commonly associated with antiphospholipid syndrome, which is characterized by recurrent thromboses, including deep vein thrombosis and pulmonary embolism, as well as complications during pregnancy. The presence of lupus anticoagulant leads to a paradoxical increase in clotting, despite its name suggesting a tendency toward bleeding.

In conditions like hemophilia A, the issue is a deficiency of clotting factors, which leads to bleeding disorders, making them unrelated to the effects of lupus anticoagulant. Similarly, vitamin K deficiency primarily affects clotting factor synthesis and is associated with bleeding, not thrombosis. Therefore, recognizing that lupus anticoagulant has a strong correlation with thrombotic events highlights its role in promoting clot formation rather than causing bleeding, confirming why thrombosis is the correct association.