Normal PT and APTT results in a patient with poor wound healing may be associated with:

The association of normal PT (Prothrombin Time) and APTT (Activated Partial Thromboplastin Time) results in a patient experiencing poor wound healing is primarily linked to Factor XIII deficiency. In the coagulation cascade, Factors VII and VIII are involved in the extrinsic and intrinsic pathways, respectively, and their deficiencies would typically prolong PT and APTT, leading to coagulopathy. Factor XII deficiency, on the other hand, is known to be related to the intrinsic pathway but generally does not have a significant impact on bleeding tendencies, meaning that patients typically do not present with abnormal bleeding or wound healing issues.

Factor XIII, also known as fibrin-stabilizing factor, plays a crucial role in the final stages of blood coagulation. Its main function is to stabilize the fibrin clot by cross-linking fibrin strands, which enhances the strength and durability of the clot. A deficiency in Factor XIII often presents with normal PT and APTT results because it does not directly impact the pathways measured by these tests. However, the lack of cross-linked fibrin leads to poor clot stability, which can result in inadequate wound healing. Hence, when considering normal coagulation profile findings alongside symptoms of poor wound healing, Factor XIII deficiency