One of the complications associated with severe hemophilia A is:

Hemarthrosis, which refers to bleeding into the joints, is a significant complication associated with severe hemophilia A. In this condition, the deficiency of factor VIII results in an inability to effectively form clots, leading to spontaneous or trauma-induced bleeding episodes. When bleeding occurs in the joints, it can cause swelling, pain, and long-term damage to the joint tissue if not appropriately managed.

In patients with severe hemophilia A, bleeding episodes can occur more frequently and are often more severe, particularly after minor injuries or even without any obvious cause. Over time, recurrent hemarthrosis can lead to chronic joint problems, including arthritis and joint deformity.

Other complications, such as mucous membrane bleeding, although relevant, typically do not pose as severe or recurrent issues as hemarthrosis does in the context of severe hemophilia A. Mild bleeding during surgery is also common in hemophilia, but it does not highlight the specific and severe complications like hemarthrosis. Immune-mediated thrombocytopenia is not a direct complication of hemophilia A; rather, it is a different condition related to low platelet counts due to immune response.