Spherocytes differ from normal red cells in all of the following except:

Spherocytes are abnormally shaped red blood cells that have a more rounded appearance compared to the typical biconcave disc shape of normal red cells. This alteration affects several of their physical properties.

When evaluating spherocytes, they demonstrate decreased surface area relative to their volume, leading to a more spherical shape. Normal red blood cells have a larger surface area due to their biconcave structure, which facilitates gas exchange and flexibility.

One of the defining characteristics of spherocytes is the absence of central pallor. In normal red blood cells, the biconcave shape creates a light area in the center, but due to the spherocytes being more filled and rounded, this central pallor is not present.

Spherocytes are also less resilient to osmotic stress; they have decreased resistance to hypotonic saline. In environments where they are exposed to hypotonic solutions, spherocytes are more likely to hemolyze than normal red blood cells due to their altered membrane structure.

However, spherocytes actually have decreased deformability compared to normal red cells. Their round shape makes it more difficult for them to squeeze through narrow capillaries and small vessels. This loss of deformability contributes to various complications, including hemolysis