Thrombin-thrombomodulin complex is necessary for activation of:

The thrombin-thrombomodulin complex plays a crucial role in the regulation of hemostasis by facilitating the activation of Protein C. When thrombin binds to thrombomodulin, which is expressed on the endothelium, this binding alters the activity of thrombin so that it activates Protein C instead of promoting fibrin formation.

Once activated, Protein C has an anticoagulant effect by cleaving and inactivating Factors Va and VIIIa, which are essential for the coagulation cascade. This action helps to prevent excessive clotting and maintains the delicate balance of coagulation and anticoagulation within the bloodstream.

This mechanism highlights the critical function of the thrombin-thrombomodulin complex in the intrinsic pathway to circumvent potential thrombotic conditions, emphasizing its importance in maintaining homeostasis in the vascular system.