What would be the most likely classification by the WHO for FAB AML M7 according to the French-American-British classification?

The World Health Organization (WHO) classification system for acute myeloid leukemia (AML) has evolved to incorporate various genetic and clinical findings. The French-American-British (FAB) classification recognizes different subtypes of AML, including AML M7, which is characterized by megakaryoblastic differentiation.

Classification under the WHO recognizes AML M7 primarily as a type that does not typically fit into the categories defined by recurrent genetic abnormalities or multilineage dysplasia. Instead, it stands out due to its unique features, like its clear histological appearance and the lack of established genetic markers that would classify it into the other recognized categories.

Therefore, AML M7 is categorized as "Acute myeloid leukemia not otherwise categorized." This highlights its distinct attributes and the necessity to study it further, recognizing that it may not share the same genetic predispositions as other subtypes in the WHO's more refined classification system.