Which AML cytogenetic abnormality is associated with acute myelomonocytic leukemia with marrow eosinophilia?

The association of acute myelomonocytic leukemia (AMML) with marrow eosinophilia is primarily linked to the cytogenetic abnormality known as inv(16). This inversion results in the formation of a fusion gene (CBFβ-MYH11), which plays a crucial role in the pathogenesis of this specific type of AML. The presence of eosinophilia in the marrow is a characteristic feature of this subtype and is directly related to the effects of the associated genetic alteration.

Patients with inv(16) often display a distinct clinical presentation, including the proliferation of eosinophilic cells, which can impact their overall prognosis and treatment strategy. Understanding this specific cytogenetic alteration is essential for diagnosis, as it not only indicates the type of leukemia but also influences therapeutic decisions and potential responses to treatment.

Other options represent different cytogenetic abnormalities associated with other subtypes of AML, but they do not have the same strong correlation with eosinophilia in the marrow as inv(16) does in the context of acute myelomonocytic leukemia. Hence, knowing the specific relationship between inv(16) and eosinophilia helps clarify the underlying biology of this leukemia subtype.