Which clinical effect is specifically associated with TTP that differentiates it from other disorders?

The clinical effect specifically associated with Thrombotic Thrombocytopenic Purpura (TTP) that sets it apart from other disorders is the presence of neurological symptoms. TTP is characterized by a pentad of clinical features: microangiopathic hemolytic anemia, thrombocytopenic purpura, acute renal failure, fever, and neurological manifestations. The neurological symptoms may include confusion, seizures, and strokes, which arise due to the formation of small blood clots in blood vessels, leading to ischemia in the brain.

These neurological symptoms are a critical aspect of TTP, helping to distinguish it from other hematologic conditions. For instance, while other disorders may also produce some level of neurological impact, the combination of severe thrombocytopenia and hemolytic anemia seen in TTP, along with its specific set of symptoms, particularly points to TTP as the underlying cause. Thus, the presence of these neurological symptoms serves as a hallmark feature in the diagnosis of TTP, making it a chief differentiator from other similar disorders.