Which leukemia is included in the 2008 WHO classification of myeloproliferative neoplasms?

The 2008 World Health Organization (WHO) classification provides a comprehensive framework for categorizing myeloproliferative neoplasms (MPNs), which include several types of leukemias characterized by the overproduction of blood cells. Chronic myelogenous leukemia (CML) is recognized as a significant type of MPN associated with the Philadelphia chromosome and the BCR-ABL fusion gene, leading to an increase in myeloid cells, particularly neutrophils.

Chronic neutrophilic leukemia (CNL) is specifically characterized by a sustained increase in neutrophils without the Philadelphia chromosome indicative of CML, representing a distinct subtype under the MPN classification. Chronic eosinophilic leukemia (CEL), on the other hand, involves an excess of eosinophils in the blood and bone marrow and is included in the MPN category as well, often associated with various genetic mutations.

By encompassing all three types—chronic myelogenous leukemia, chronic neutrophilic leukemia, and chronic eosinophilic leukemia—the correct response accurately reflects the WHO classification, which recognizes these conditions as part of the umbrella of myeloproliferative neoplasms. Thus, all of the specified leukemias are included in this classification