Which of the following clotting factors are activated by thrombin that is generated by tissue pathway (TF-VIIa)?

Thrombin, generated through the tissue factor (TF) and factor VIIa pathway, plays a critical role in the coagulation cascade. Specifically, thrombin activates several key clotting factors that are essential for promoting platelet activation and furthering the coagulation process.

The correct answer highlights the activation of factors V and VIII. When thrombin is formed, it cleaves and activates factor V, which then serves as a cofactor for the prothrombinase complex, enhancing the conversion of prothrombin to thrombin. Additionally, thrombin also activates factor VIII, which is crucial for the propagation of the coagulation pathway, particularly in the activation of factor X when combined with factor IXa.

Factors XII and XI, as referenced in the first option, are part of the intrinsic pathway and are not activated directly by thrombin generated through the tissue factor pathway. Factor I corresponds to fibrinogen, which is converted to fibrin by thrombin, but the critical activation by the pathway in question pertains explicitly to factors V and VIII.