Which of the following Hgb configurations is characteristic of Hgb H?

Hemoglobin H is characterized by a specific tetrameric configuration composed of four beta chains, represented as β4. This configuration occurs due to a lack of sufficient alpha globin chains, which is typical in certain types of alpha thalassemia. In conditions leading to Hemoglobin H, the body compensates by producing excess beta chains that aggregate together to form this unique structure. The presence of this configuration indicates a pathophysiological state where the alpha chain production is insufficient, leading to the synthesis of beta chain tetramers instead.

The other configurations listed do not accurately represent Hemoglobin H. For example, gamma and beta configurations would correspond to other types of hemoglobin, but not to Hemoglobin H specifically. Understanding these specific structures helps identify and differentiate various hemoglobinopathies.