Which of the following is associated with multiple factor deficiencies?

Severe liver disease is associated with multiple factor deficiencies because the liver is responsible for the synthesis of most coagulation factors. When the liver is impaired, the production of these factors, including prothrombin and factors V, VII, IX, and X, is reduced, leading to a coagulopathy characterized by a deficiency of multiple clotting factors.

In situations where liver function declines, either due to cirrhosis, hepatitis, or acute liver failure, the synthesis of proteins essential for normal blood clotting is compromised. This can manifest as a bleeding tendency in affected individuals. Therefore, the association of severe liver disease with multiple factor deficiencies is a well-documented phenomenon in hematology practices.

In contrast, inherited disorders of coagulation typically affect specific factors rather than multiple ones at once. Dysfibrinogenemia primarily involves abnormalities in fibrinogen levels or function, but does not systematically cause deficiencies in multiple coagulation factors. Lupus anticoagulant can lead to prolonged clotting times and has an association with thrombosis rather than deficiencies of clotting factors themselves.