Which of the following is most commonly associated with activated protein C resistance (APCR)?

Activated protein C resistance (APCR) is most commonly associated with thrombosis, specifically venous thromboembolism. This condition occurs when there is a genetic mutation in the factor V protein, commonly known as factor V Leiden, which leads to a decreased ability of activated protein C to inactivate factor Va and factor VIIIa, both of which are crucial in the coagulation cascade. The impairment results in a tendency for the blood to clot more readily, increasing the risk of thrombotic events, such as deep vein thrombosis (DVT) and pulmonary embolism.

In contrast, bleeding is not typically associated with APCR; rather, patients often experience an increased risk of clotting events. Conditions like epistaxis and menorrhagia are related to bleeding disorders and are not directly linked to activated protein C resistance. Therefore, the association of APCR with thrombosis highlights the mechanism involved in the coagulation pathway disruption caused by this disorder.