Which of the following statements about osteoclasts is true regarding multiple myeloma?

Osteoclasts play a crucial role in bone metabolism, particularly in the context of multiple myeloma. These cells are specialized for bone resorption, meaning they break down bone tissue. In doing so, osteoclasts release calcium and other minerals from the bones into the bloodstream, contributing to maintaining calcium homeostasis in the body.

In the case of multiple myeloma, a malignancy characterized by the proliferation of abnormal plasma cells, there is often an imbalance in bone remodeling. The activity of osteoclasts is heightened, leading to increased bone resorption. This can result in bone pain, fractures, and elevated levels of calcium in the blood (hypercalcemia), which are common complications associated with the disease.

The other statements do not accurately describe osteoclasts in the context of multiple myeloma. Osteoclasts do not promote bone formation; that role typically belongs to osteoblasts. They are not inhibited by monoclonal gammopathy; instead, their activity is often increased in multiple myeloma due to the tumor's influence on bone metabolism. Additionally, osteoclasts are not characteristic of benign conditions; in fact, their increased activity and number in multiple myeloma and other malignancies are