Which red cell indices are characteristic of megaloblastic anemias?

Megaloblastic anemias are characterized by ineffective hematopoiesis and are often associated with deficiencies in vitamin B12 or folic acid. One of the hallmark features of megaloblastic anemia is an elevated mean corpuscular volume (MCV), typically greater than 100 fL, reflecting the presence of large, abnormal red blood cells known as macrocytes.

In the given choices, the option with an MCV of 125 fL aligns with this characteristic, indicating significant enlargement of the red blood cells. Additionally, megaloblastic anemias usually show an increased mean corpuscular hemoglobin (MCH), which can also be seen in the chosen option. The elevated MCH suggests that the larger red cells carry more hemoglobin, which is consistent with the macrocytic nature of these cells.

While the mean corpuscular hemoglobin concentration (MCHC) can vary, megaloblastic anemias typically do not lead to a low MCHC, further supporting the overall indicators seen in the chosen option.

In summary, the values in the selected answer accurately reflect the typical blood profiles observed in megaloblastic anemias, characterized by macrocytic red cells with a high MCV and