Which statement regarding protein C is correct?

Protein C is a crucial component of the coagulation system, playing a significant role in regulating blood clotting and maintaining hemostatic balance. When activated, protein C works synergistically with protein S, which acts as a cofactor to enhance its anticoagulant effects. This activation leads to the inactivation of factors Va and VIIIa, thereby reducing the generation of thrombin and inhibiting further clot formation.

This process is vital for preventing excessive clotting and ensuring that the body can regulate blood flow effectively. The interaction between protein C and protein S is necessary for the full activity of protein C, signifying that the letter choice highlighting this relationship is indeed accurate. Understanding this mechanism is essential for comprehending the complexities of the coagulation cascade and the regulation of clot formation.