Which symptom is commonly seen in CML but not in acute myeloid leukemia?

In Chronic Myeloid Leukemia (CML), splenomegaly is a hallmark symptom that is frequently observed due to the accumulation of abnormal blood cells in the spleen as the disease progresses. Unlike acute myeloid leukemia (AML), where the rapid proliferation of immature myeloid cells typically doesn't lead to significant splenic enlargement early in the disease course, CML often evolves over time, leading to notable splenic involvement. This enlargement is a result of the body's response to the chronic overproduction of myeloid cells, and it can contribute to the sensation of fullness, discomfort in the abdomen or left upper quadrant, and potential complications from increased pressure on nearby organs.

Both elevated white blood cell counts and recurrent infections can occur in both CML and AML due to the nature of leukemia affecting white blood cell production. Bone pain can also be present in AML due to leukemic infiltration of the marrow or associated pressure in the bone cavities, making them less distinctive compared to splenomegaly, which is more characteristic of CML. Understanding these differences can help in diagnosing and differentiating between the two conditions.