Which type of leukemia primarily affects granulocytic precursors and is sensitive to Sudan Black B staining?

Acute myeloid leukemia is characterized by the proliferation of myeloid precursors in the bone marrow and is known to primarily affect granulocytic precursors. This type of leukemia results from mutations in the hematopoietic stem cells that lead to the rapid and uncontrolled growth of myeloid cells.

One of the hallmark features of acute myeloid leukemia is its sensitivity to Sudan Black B staining. This staining method is used to identify the presence of lipids in the cells. In the context of acute myeloid leukemia, granulocyte precursors typically contain lipid-rich granules, making them stain positively with Sudan Black B. This positive reaction can help differentiate acute myeloid leukemia from other types of leukemia, particularly those that do not primarily involve granulocytic lineage.

The other types of leukemia listed do not primarily affect granulocytic precursors or have distinct cellular characteristics that do not respond to Sudan Black B staining. For instance, acute lymphocytic leukemia mainly involves lymphoid progenitors and thus would not exhibit the same staining properties. Chronic myelogenous leukemia, while also a myeloid disorder, is characterized by a more gradual accumulation of myeloid cells and typically shows different staining patterns compared to acute myeloid